The postal service says that it will need as many as 142,000 half-ton trucks to send the holiday mail this year.
A total of 190,000 vehicles will be used in order to deliver the 16.6 billion letters cards and packages being sent around the US this Christmas.
The service is also expecting 97 million customers to visit post offices around the country, and an additional 41 million to use USPS's new online shipping service.
John E Potter, the postmaster general and chief executive, said that "the holiday season isn't just the busiest time of the year for the Postal Service it's our best time of year".
He added: "We've been delivering the holidays for the past 234 years, and we're proud to deliver excellent service to our customers, especially during this busy time of year
we're the holiday mailing and shipping experts."
USPS estimates that a total of 2.11 billion stamps will be used over the holidays, with this year's cards featuring an image of Kermit the Frog on postage stamps.